A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Casts
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Michael Carven
Additional Character Voices (voice)
Crew
Bobby Farrelly · Peter Farrelly · Marc HymanDirected by Bobby Farrelly
Watch trailer
Trailer provided by the rights holder via YouTube.
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